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Mechanistically, utilizes molecular oxygen inserting one oxygen atom into a substrate, and cutting down the next into a water molecule, with two electrons furnished by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). CYP3A4 is predicted to become the key CYP enzyme liable for mediating etizolam metabolism. CYP2C18 and C
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